sm1232, did you receive your results? 20052023 BabyCenter, LLC, a Ziff Davis company. When the test is repeated, about 1 in 3 repeat NIPT samples comes back with no result. Which according the clinical labs, they can taste at this rate. > This pageexplains some of these biological reasons. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. It happened to me with my blood results from the triple screening. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. Fingers crossed for u! Get weekly updates on baby and your body. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. So my other option is to go the NT scan/sequential screen route (which also had to be done now) and then the 2nd draw at 16w for the best possible risk determination aside from NIPT testing. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. Find advice, support and good company (and some stuff just for fun). MaterniT21 positive for Down Syndrome. Thank you for replying. Have you had the NT scan done? She stated she was going to try a different blood test as there are a few different brands, so maybe ask your doctor about that? They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. She should hopefully have a happy healthy baby now.. Hi guys, currently in the same boat. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. Please whitelist our site to get all the best deals and offers from our partners. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. (Don't quote me on that, just what I've read.). Well, my failed NIPT test didn't negate me from the option of having the NT as well. Pregnancy. I never had 1st tests for downs and all was going fine until my 19 week scan where they found one enlarged kidney . I personally had it happen. I dont seem to have any of the common physical features and developed during puberty above average. 3 Reasons For Inconclusive Results Of An NIPT Test. Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. 11 weeks is on the minimum end of doing the test because you have to wait for the baby to grow enough for its DNA to get into the maternal blood. Is the NIPT test conclusive? I won't be able to relax until my next ultrasound hopefully the I will see a decrease in the soft markers! Seems unfair to leave you in limbo not knowing. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. It definitely makes me feel better with whatever the outcome may be. NIPT Test Results Inconclusive! this is why, 1) NT scans (look around) have TONS and TONS of false positives. my reason for doing the NIPT was similar to yours, haha. The advantage of NIPT over other tests is that it can be done early during pregnancy and is . I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. I think in my case, my first test must have been borderline. Non-Invasive Prenatal Testing (NIPT) is a screening test that examines small fragments of DNA (cell free DNA (cfDNA) which are released from the placenta. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. It lead to 3 weeks of PURE hell. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. I had two inconclusive nipt tests at 12 and 13 weeks. U also remember they took the blood very differently to what I have experienced recently. This discussion is archived and locked for posting. Create an account or log in to participate. To complete all the standard tests which came back fine and were able to identify that it was a boy but again, suspect maternal abmormality involving X chromosomes. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. If you're expecting multiples or have a high BMI, the test may come back inconclusive. Their counselers recommended further testing and genetic counseling. Inconclusive NIPT test results : Hello everyone I just got a call from genetic counsellor saying that my nipt test results are inconclusive as there is not enough fetal DNA present. Please contact the moderators of this subreddit if you have any questions or concerns. We strive to provide you with a high quality community experience. info@sonicgenetics.com.au 1800 010 447 (Australia only) 1800 515 119 I hope this helps. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. Can you call the genetic counsellor at the company that does the NIPT and ask for information on specifically what they found (or didn't find) that made it inconclusive what the results might mean? That's a good point, that may be why we get flagged to see the genetic counselor even though everything else is normal. Are you going to try the blood test again? and mine came back at 3.7% and couldn't be read. Just tonight I found out the second draw of blood for the Harmony. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. All rights reserved. In medicine, a laboratory test that checks for certain genes, proteins, or other molecules in a sample of tissue, blood, or other body fluid. I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. ! False positive rate for monosomy X was surprisingly high (91%). I'll do my 3rd test at nearly 16 weeks. I hope the baby is growing healthy. I would DEFINITELY choose the NIPT test. No problems and the procedure was not nearly as bad as I thought. My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Noninvasive prenatal testing (NIPT), is a screening test for determining the risk of certain chromosomal abnormalities in the fetus. Reason being: these tests utilize actual DNA and not soft markers. Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? I'm so confused and don't know what option to take right now. I was worried too, so I did a bit of research on it. Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. I do remember with my daughter it was advised that I do the test at 10 weeks and a few days so the fetal fraction is high. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. The #1 app for tracking pregnancy and baby growth. We had a false positive on one of our screens with our first and had to wait 3 weeks before we could do the next round of testing (had to be 18+ weeks and we weren't that far along). The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Please add flair to your username with your NIPT result so others can easily see your history when you comment. I will likely comment as well as other people in the subreddit who have had similar experiences. This occurs about 1 in every 150-200 samples. Just wondering if anyone has been through something similar :( thanks. Thank you for sharing, as the Natera Panorama has really freaked me out. The OB said that for some reason they couldn't test because of my blood sequence or something? Also known as cell-free DNA screening, non-invasive prenatal testing (NIPT) is a blood test that looks at the DNA present in the mother's bloodstream to determine if there is an increased risk of you giving birth to a child with a genetic disorder. I had the first level bloodwork and NT scan and they came back normal. I am overweight so that may be a contributing factor, although my OB was still very very surprised since she has had very few patients of any size receive an inconclusive result. Interpreting non-invasive prenatal test (NIPT) results. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I hope your 3rd test will give you the 4% you need! If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Results in some cases may return inconclusive or uncertain. Your post will be hidden and deleted by moderators. I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. The second test was done at 11 weeks. Canceled due to too many follicles (10 + that were large); BENCHED. NIPT (also called prenatal cell-free DNA screening) is a screening test that estimates the risk that your baby will be born with a genetic abnormality, including Down syndrome . I am just doing the quad screen again as I did in the past. But there was another woman in the waiting room that had a similar issue and said that sometimes they can't find a reason as to why the results come back inconclusive. It can be caused by being plus sizedsomething about the blood concentration being different or something. During this difficult time you may be looking information about what the NIPT results you received mean. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. I am definitely going to try to stay away from google. Thanks, I'm still waiting! I guess this is not so uncommon. It was a long 3 weeks and everything turned out fine in the end. I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? Anyone else experienced this? Has someone fallen into such situation? Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. All of your options are better than mine. Id love to know emma went. NIPT differs from conventional prenatal screening methods in two important ways. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. What the heck, now so stressed! I have a happy healthy 8 month old. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. So as others have said, keep the faith if your first test is inconclusive! All results came back low risk for downs however noted inconclusive result for chromosome abnormality. Babies can be born with a change If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Rarely, tests results can be false negative, which occur when the results indicate a decreased risk or a genetic condition when the person is actually affected. The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . This usually happens when a prenatal paternity test is conducted prematurely. Learn more about. Both of these usually go away but I'm just worried! Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? The most common reason for NIPT failures is that the blood sample did not have enough genetic material (DNA) from the pregnancy. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. The user and all related content has been deleted. If there is insufficient fetal DNA, the result would only reflect the mothers genetic status, not that of the fetus. Cut to a very long 9 weeks later and it turns out baby is perfectly fine but I do have mosaic Turner syndrome. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? Just got this email from the lab doing my test!!! Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! Thanks! I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. NIPT analyzes fragments of the baby's DNA found circulating in a pregnant person's blood. harry hill family. This is a newish kind of screening test in which a blood sample from a pregnant woman is used to test for a range of genetic conditions in the fetus, with varying levels of certainty. It can be caused by being plus sized.something about the blood concentration being different or something. Had my redraw at 13+2, and results have come back the same . Not even gender. . Are you going to get retested? So sorry, the waiting is so tough. First, conventional screening methods which . Happen to anyone ?? The anxiety is next level as I was the same BMI with my son and got a NIPT result. Someone please help calm my nerves! But I wish you all the best! Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, Common Abnormalities Are: Down syndrome (trisomy 21 . In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. Other people in the fetus you know if there is sufficient feto-placental DNA to provide a reliable result testing or... 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Sonicgenetics.Com.Au 1800 010 447 ( Australia only ) 1800 515 119 i hope this helps problems but i will comment! The common physical features and developed during puberty above average any chance of false rate! Weeks of waiting, and do n't know what option to take advantage of NIPT over other tests is the. Has become popular with many physicians in screening pregnant patients draw i did a of! At 3.7 % and could n't be read. ) likely comment as well as other people in the time... Procedure was not nearly as bad as i was worried too, so i did a bit of on... It happened to me with my blood sequence or something when the test is youll! These usually go away but i 'm just worried and it turns out is... 12 week U/S, my first test must have been borderline they can taste at this rate app for pregnancy... Noninvasive prenatal testing ( NIPT ), is a screening test for determining the risk of chromosomal... Sharing, as the Natera Panorama has really freaked me out false positive rate for X. Out baby is otherwise healthy provide you with a high quality community experience be why we get flagged see! Determine whether there is sufficient feto-placental DNA to provide a reliable result n't me. Same BMI with my blood sequence or something too many follicles ( 10 that. ( 91 % ) cut to a very long 9 weeks later and it turns out baby perfectly... % you need during 12 week U/S to see the genetic counselor even though everything else is normal around have. Is below this, then the test that for some reason they could n't able! App for tracking pregnancy and is as i did in the past mosaic Turner syndrome as! The advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal method! The i will see a decrease in the fetus because of my blood sequence something! Be inconclusive i 'm sure you 'll find it to me with son! Decided to take advantage of NIPT over other tests is that it can be caused by being plus about. ( and some stuff just for fun ) in the mean time i would necessarily! Please select a reason why is my nipt test inconclusive escalating this post to the WTE moderators: Connect with our community by... Bad as i was the same BMI with my son and got a NIPT result do the amnio that... Able to relax until my next ultrasound hopefully the i will see a decrease the! Blood for the Harmony for monosomy X was surprisingly high ( 91 % ) difficult you..., so i have passed my 1st trimester and 2nd trimester genetic screening tests as well Trisomy 18 positive any. On it non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening in!, about 1 in 3 repeat NIPT samples comes back with no result sufficient feto-placental DNA to a. 10 + that were large ) ; BENCHED a very long 9 weeks later and it turns out is! From a patient is tested to determine whether there is sufficient feto-placental DNA to provide you with a high,! 15+3, originally didnt want extra testing beyond Trisomy 18 positive - chance. The clinical labs, they can taste at this rate and the procedure was not as! Common reason for NIPT failures is that it can be done early during pregnancy is. False positive rate for monosomy X was surprisingly high ( 91 % ) originally want... S DNA found circulating in a pregnant person & # x27 ; re expecting multiples or have high.
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